how to activate cbd

Decarboxylation of CBD and THC– That’s How You Activate Cannabis

As the way to someone’s heart is through their stomach, it’s no surprise that cooking and baking with cannabis is growing in popularity. In order to enjoy their pharmacological effects, THC and CBD need to be decarboxylated. Or to put it another way: no heat, no high!

Decarboxylation is a horrible word. It reminds many of us of those awful school chemistry lessons. But anyone who is interested in cooking and baking with cannabis needs to know what decarboxylation is all about.

Let’s start at the beginning: Cannabis consists of hundreds of cannabinoids. The best known of these, THC and CBD, are present in the plant in the form of what are known as carboxyl acids. This is why in this form they are also referred to as THC-A and CBD-A (‘A’ stands for acid).

When you heat these substances, the acid releases a carbon dioxide molecule in a process known as decarboxylation or activation. This is, in fact, the natural process of decay and the application of heat just serves to speed it up.

Why do you need to decarboxylate your cannabis? Purely and simply because this is the only way to obtain its pharmacological or healing effects.

Here’s how you decarboxylate properly!

The basic rule is: the higher the temperature, the faster the cannabinoids will be activated. When you smoke a joint, you are decarboxylating the cannabis as you do so. And even when you steam your cannabis using a vaporizer, a few seconds is all it takes to convert THC-A into THC. By the way, the steamed cannabis left in a vaporizer is fully activated, is usually still very potent and can be eaten straight away.

When decarboxylating, the cannabis should not be heated for too long, as this can create inactive products of decomposition. You particularly need to avoid the oxidation of THC into CBN (cannabinol).

A patent owned by the UK company GW Pharmaceuticals defines the ideal conditions for decarboxylation: It involves low temperatures and a relatively long period of heating. This process ensures that 95% of the cannabinoid acids are converted into their phenol form without many decomposition products being created. Another benefit: The aromatic terpenes remain intact. Terpenes are responsible for the aroma, taste and they also influence the effect of cannabis.

According to the patent, decarboxylation in a lab setting should be carried out in two steps:

  1. First heat the cannabis briefly, to make any remaining moisture evaporate.
  2. Then heat the plant material twice more for longer periods.

The best results involve 15 minutes at a temperature of 105°C and then 60 to 120 minutes at the same temperature.

If you are using a marijuana variety which has a very high CBD content, (defined as >90% CBD as a percentage of the total cannabinoid content), then the second phase needs to be 30 minutes at 140°C.

Related post

WHO Recommends Cannabis Reclassification: What Does it Mean for THC and CBD?

Tea, butter or cookies? It all depends on the final product

Please note that the above instructions are based on ideal conditions created in a laboratory. If reading this has dampened your enthusiasm for baking, let’s soften the blow. You don’t have to stick to precise temperatures and times. Depending on what you are going to use the activated plant material for, there are only good and less good methods of preparation.

Let’s say you want to make some marijuana tea. If you pour boiling water over the buds and leave everything to brew for 5 to 10 minutes, the cannabinoids will not be fully activated. At 100°C, the plant material needs to be heated for at least 1 hour. A common practice is to heat the material in a closed pickling jar for an hour in a water bath. The result: Cannabis with plenty of flavour and strong effects! Make sure to heat up the water slowly as rapid changes in temperature increase the risk of glass breaking.

It is even simpler if you want to bake tasty cookies or cakes. Most baking recipes give near-perfect results. Avoid any temperatures above 155°C, because at that temperature, the THC starts to evaporate.

To make cannabutter, the best method is again a pickling jar in a water bath. Afterwards, boil the activated plant material with butter and water for at least one hour, strain to remove the buds and leaves, and leave to cool. The active butter can then be scooped off the top of the cooled liquid. Once frozen, the hash butter can be kept for a very long time.

And one final tip: for the best results, you should crush or grind the plant material before activating it.


32 thoughts on “Decarboxylation of CBD and THC– That’s How You Activate Cannabis”

Hi! I bought some cbd buds online and decided to make my own cbd oil with coconut oil at home. I didn’t have a thermometer to check how hot it got. I did eat two teaspoons of the finished oil which probably means I had way too much and it made me super sleepy and wasn’t a nice high at all. Is it safe to make your own cbd oil at home? Is it true that you can increase the thc levels with heat? I really dont get on with thc too much. I was also reading that maybe the oil got too hot and the thc turned to cbn which is why it made me soo sleepy… but also maybe I just had too much 😛 Would love your advice as really want to be able to make my own cbd oil at home 🙂

Thanks for your comment and sharing your experiment with us. I can’t really give you advice about homemade CBD oil as I don’t have any experience with it, but I can tell you that increasing the temperature of a vaporiser releases more THC – however, you really have to do it carefully and know what the temperatures are. Maybe one of our readers has had success with making their own CBD oil?

Good luck, and as always, take care around hot oil.

With best wishes,

What is the best way to transform your weed into cbn?
How long in the oven and how many degrees?

I couldn’t find a definite answer to this question (it seems that CBN is a less-wanted cannabinoid) but there is advice that says to avoid converting THC into CBN, you should only have it in the oven for an hour, at temperatures of no more than 120 degrees Celcius. So you could experiment with increasing the time and the temperature.

You might also find this article about CBN interesting, if you haven’t already seen it. Good luck!

With best wishes,

Curious about decarbing directly into hot oil. I have an induction cooktop I use for holding temps at a very precise level for brewing beer. If the decarb process is all about the proper application of heat, it seems logical that a preheated oil bath would decarb perfectly and quite possibly in a shorter period of time due to the low specific heat of oil, which translates to a faster transfer of heat to the plant material and a more precise and constant temperature due to the nature of an oil bath (faster/more consistent than a water bath or heated air in a typical oven). I’ve looked around and most old schoolers can’t answer this question except to say, “It absolutely must be decarbed in an oven first.” Am I missing something? Does anyone have experience trying this?

This is an interesting question! My personal experience is of making cannabutter, which involves simmering the cannabis in repeated lots of fresh water before finally adding it to fat and simmering it in the fat for quite some time, all of which serves to decarboxylate it. Then the fat solidifies on top, also removing all the water and other moisture from the fat.

I do wonder if the ‘decarboxylate in an oven’ principle is also to do with removing moisture from the bud before it’s added to oil. Would you end up with a thin layer of water under your oil if you used fresh buds?

I don’t have an induction cooktop but I’m really interested in this topic. Please do let me know how you get on, and if appropriate I’ll update this article.

With best wishes,

Great article and discussions by all. Glad I found this blog site today.

Does anyone know of any benefit, medicinal or psychoactive, to using fresh, raw cannabis sublingually? That is, placing a small amount of fresh, raw bud under the tongue and holding there until fully absorbed and integrated via the saliva into your system? Alternatively, would this be any different than simply eating the herb in raw form (i.e. mastication)? Or are both methods just a waste of time, and herb?

Thank you in advance for all shared insights!

Thanks for your kind words, it’s always lovely to have positive feedback 🙂

The answers to your questions are quite detailed, and can be found in this post about juicing raw cannabis leaves. I hope this gives you enough information, and that you continue to enjoy the blog.

With best wishes,

Hello, question,
You say to decarb at low temp 105C to preserve terpenes. But once cannabutter is made, you said to bake with it at 155C or below to avoid THC evap. Wouldn’t all the terpenes and compounds you tried to preserve at 105C and below be lost between 105-155C??

Thanks for your question. I believe you are correct, some of the terpenes would be lost at higher temperatures, but unfortunately the baking process would not be successful at lower temperatures. So it depends what is more important to the individual, using the butter with a complete-as-possible terpene profile, or having the convenience of cake! I have known people who have solved this problem by making cannabutter and then eating it spread on toast, but it is easy to ingest quite a lot of butter like this, so be careful if you decide to try it.

With best wishes,

Hi can anyone inform me if it’s possible to decarbonise THC power that I have collected in a THC grinder?

I’m guessing that you have used a grinder for herbal cannabis with a screen for the trichome ‘dust’ to fall through and be collected? This powder is probably partly decarboxylated already as the cannabis will have aged whilst drying and curing before you could grind it. You could mix the powder with edible fat like coconut oil and gently heat it following the instructions in this article, and that should work.

If I’ve misunderstood your question, please let me know! In the meantime, I hop you continue to enjoy the blog.

With best wishes,

Hello there. I got a green powder from a friend saying hat this is the whole plant crushed to powder . Leaves. Buds .. and everything. And it has mostly cbd that thc in it .. can some one help me here please? I guess i need to activate it with heat right !?

Should i do ot with oven ? As mentuoned in the first 2 methods or should i do it with jar snd waterr heat ?

Thank tou in advance

My advice would be to not try this process with anything that you are not 100% sure is cannabis – ‘green powder’ could be anything! Also, powder is difficult to work with for either the water or oven methods.

With best wishes,

I add 7g of semi-ground up dried non-decarboxylated cannabis bud to a large mason jar. I then pour approx. 1/4 cup of warmed up organic coconut oil(solid at room temp) over the bud. I like to add enough oil, approx. 1/4 inch above the herb, for proper infusion. I then lightly screw on the mason jar lid & immerse in water up to an inch & a half below the jar’s lidded threads which is well above oil in the jar. The jar is set on an elevated tray within the pot so that it does not make direct contact with the heating surface. I then place a weight on top of the lid to keep the jar in place, bring to a slow boil & simmer(200F) for 4.5 hours, gently agitating the jar every 30 mins & opening the lid a couple of times early on to let co2 escape – though some co2 should escape as I don’t screw the lid on air tight.
It’s important to always maintain the same volume of simmering water throughout the 4.5 hours to ensure adequate decarboxylation & infusion.

After 4.5 hours I strain the oil through a fine metal strainer into another smaller bottle & put the compressed coconut soaked plant material into a bowl & store in the fridge which I’ll later add to my teas. When the bottle of strained oil(absent of plant material) cools down, but before it solidifies, I add approx. 1/2 ml to each gelatin “0” sized capsule & then put them in the fridge immediately so that the coconut oil solidifies within each cap. This is done to minimize the chance of the capsules melting. I’ve made a few batches & stored the capsules at room temp(coconut oil remains solid) up to a month & have never had a leaking/melting issue thus far.

The bowl in the fridge containing the coconut cannabis soaked plant material works super well as an additive to tea. I add a small clump to the hot tea & let stand for 10 seconds, strain the plant material off leaving the coconut oil & tea behind. It taste great & is surprisingly effective.

Thanks again Scarlet 🙂

Thanks so much for this very detailed and easy to follow explanation. I’ve got some trim from the year before last that I keep thinking I should do something with, so I’m going to give your method a try!

Wishing you all the best,

Does it convert the THC in the CBD high % enough to cause a “high”? Like in a CBD flower low% THC pre-roll if this method is followed?

Would dried CBD dominant cannabis, at 15%CBD & 0.5%THC, decarboxylate simply by placing the dried ground bud in a lightly sealed mason jar with coconut oil & immersing the jar, up to the bottle’s neck, in a simmering water bath(200F) for 3-4 hours be sufficient to decarboxylate & infuse?
Thanks muchly – Deb

My apologies for it taking so long to respond to your comment, I overlooked it in the recent blog update.

Regarding your question; I’ve never personally tried this method, but it sounds to me like it should work. However, it is very important to ensure the bud is absolutely clean before you start the process, otherwise any dirt and residue of nutrients, pesticides, etc will also be retained in the coconut oil. It’s recommended to put the bud in a pan of water, bring it to the boil and simmer it for at least half an hour, then drain the water off. Repeat this process until the water remains clear. This usually takes about three goes (it’s amazing the amount of gunk that comes off!). As cannabinoids are fat-soluble rather than water-soluble, they won’t be lost during this cleaning process, although try not to bash the cannabis about whilst it’s in the water.

This is the cleaning process usually used for making cannabis fat for cooking; the next step is to add a fresh lot of water to the drained, cleaned cannabis, and then add some kind of edible solid fat (butter and coconut oil are most common) and simmer for an hour. Then turn the heat off and let it cool; the fat will float to the surface and solidify, enabling you to lift it out of the pan. And voila, cannabis-infused coconut oil!

I hope this answers your question.

With best wishes,

Update: So I made a few batches of CBD caps by immersing non-decarboxylated dried ground CBD dominant cannabis & coconut oil in a mason jar semi-sealed into a “bain-marie”(gentle boil/simmering) water bath for 4.5 hours. I’m very happy with the results.
The cannabis may not have been fully decarboxylated which is actually not a negative because CBD-A & THC-A have medicinal properties as well.
Thanks for the cleaning process tip! When cannabis is given or purchased from an unknown source your cleaning tip would be invaluable. Thanks so much Scarlet!
Deb 🙂

Thanks so much for the update and for sharing this technique with us. May I ask, did you strain the plant matter out of the coconut oil afterwards?

Regarding the cleaning tip – you’re very welcome! I feel like it’s the sort of thing that should be more widely known 🙂

With best wishes,

So, if I’ve got this correct, GW Pharma was granted a patent for decarboxylation of cannabis by heating – an old and well-known method. If this is true, then anyone who uses heating to decarboxylate is infringing on their patent; any company, any individual. And, I have learned in a different context the unpleasant way, anyone who advises or encourages one to use this method of heating to decarboxylate is violating their assigned rights. The patent offices are staffed with idiots (well, maybe just overworked and underpaid gov’t employees) who often give away patent rights without really doing any research. Then it is on the people who should own the rights to use simple and long-used methods to have to fight in court against corporate lawyers. Just be warned folks – it sure looks like they have patent rights to our basic heat decarbing process! Follow that link in the article and it is right there: “In PCT/GB02/00620 the applicant discloses a method of preparing a herbal drug extract (botanical drug Substance) from medicinal cannabis. The process comprises:
1. a heating step to decarboxylate the acid form of the cannabinoids to their neutral
form; ”

I guess that for many of us we are in the clear since we might use a “recreational cannabis” (and who knows what we do in the privacy of our cellars anyway), but any company using this method for any “medical cannabis” would be in violation of their patent. This is very troublesome.

Please read the actual patent (link was given). The extended times given in the patent application relate to the 40C temperature used in the supercritical fluid extraction process and have nothing to do with the basic decarboxylation!

The decarboxylation is simply the same thing people have been doing all along before this patent – it is nothing magic. They describe a 2-step heating for the decarboxylation. The chopped cannabis is heated to 105C for a while to dry the material; until the water is gone the cannabis can’t rise above 100C and so depending on how wet the cannabis, this would be a variable otherwise. This removal of water will occur if simply heated directly to the typical decarboxylation temperature of 110C to 115C, but driving off the water first allows for a more controlled effect of time at the 110C decarboxylation temperature; a time of 60-90 min (at temperature) is effective at decarboxylation. If you fold the cannabis into an aluminum foil packet with tightly seamed (double folded tightly) edges, it will make much less stink in your house and retain more of the terpenoids (the “stink”) that we would like in the decarbed product. Note that you can just simply eat a small pinch of the dry decarbed bud directly, but please start with a small pinch! Eating dry bud can take an hour to be noticable and last 8 hours or more – start low and go slow. Way less messy and trouble than making oils and tinctures.

Don’t use aluminium foil unless you want toxic heavy metals in your brain, thats very bad advice! Don’t use it in direct contact with food either.

First, the facts. Aluminum is not a heavy metal – chemically speaking – and is not hazardous in an application with mildly heated dry “food” materials. Aluminum has a melting point of over 1220degF and we would be heating it to 230degF in this application. Furthermore, Aluminum spontaneously forms a layer of aluminum oxide that has the higher melting point of 3762degF and is even more inert. There are accounts of substantial aluminum being dissolved from aluminum stockpots that simmer acidic tomato sauce for many hours in restaurants, but the case of heating dry plant material encapsulated by aluminum foil is not at all related. If interested, please read Wikipedia on Aluminum and read the section on Biology and Toxicity, and then you can make an intelligent decision for your own actions. Wikipedia states “There is little evidence that normal exposure to aluminium presents a risk to healthy adult, and there is evidence of no toxicity if it is consumed in amounts not greater than 40 mg/day per kg of body mass.” People should do what they are comfortable with, but use your head and look at evidence. I also don’t believe in a flat earth.

Are vaccines bad too Simon?! Aluminum foil is made from pure Al ingots squished between a couple of massive rollers. I worked at a place that made the stuff. Please stop talking out your ass there Simon. You’re very full of shit and presenting it as fact. Aluminium is not a toxin or a heavy metal. The only thing it comes in contact with is a little bit of food grade lubricant that is on the rollers and that is removed when it’s heated. It is absolutely safe to use to decarb and for food.

Simon Says….Use your brain! Well, Aluminum is not a heavy metal, neither physically not chemically, so you won’t get any heavy metals, sorry. It is atomic number 13, Atomic Weight 26.981… It is NOT a heavy metal. It IS toxic, but you aren’t going to get it by covering food in an oven.

Aluminum has the following properties:
Melting point 933.47 K ​(660.32 °C, ​1220.58 °F)
Boiling point 2743 K ​(2470 °C, ​4478 °F)
The first thing that aluminum does on heating in the presence of air (with oxygen) is form aluminum oxide, a thin layer that has a much higher melting point than aluminum.
Melting point 2,345 K (2,072 °C, 3,762 °F)
Boiling point 3,250 K (2,977 °C, 5,391 °F)

There is no way that aluminum foil will contribute aluminum to a batch of buds being decarboxylated at 120C.

Intelligently used, aluminum foil can even be used for lining a pipe bowl. Really. Again, use your head and don’t put an oxy-acetylene torch on it! With normal gentle heat to vaporize the goodies in the bud, you end up with the aluminum foil covered with tar, not evaporating the aluminum. You get a bowl with a glowing cherry, now that is a different propsition and that is not what I am talking about. You are going to get aluminum into your body from environmental sources like water, foods, food additives and drugs; it will not come from lightly heating your buds at 120C to decarboxylate the cannabinoids.

If you are interested in cooking and baking with cannabis, you need to know what decarboxylation is all about. Because: no heat, no high!

Do You Need THC To Activate CBD?

If we hear this one more time, we’re going to lose it.

“You need some THC to activate the CBD”.

It’s almost dogma in the cannabis community.

It’s one of those things that just keeps recycling among people with no real basis.

Let’s set the record straight based on research.

We’ll try to put a dent in this misconception and also discuss the opposite…

CBD offsets and counters the effects of THC.

We’re not anti-cannabis although there are some considerations with THC that people need to understand.

Let’s get into it before one more person offers that same, tired advice.

And yes. we’ll take a look at the “entourage effect” which might be the best marketing slogan since “Just Do It”.

We’ll cover these basic topics:

  • Do you need THC to activate CBD?
  • How do THC and CBD work in the body
  • Does CBD offset THC’s effects in the body
  • Can THC cause anxiety?
  • Does CBD help with too much THC
  • The effects of CBD in the body
  • The effects of THC in the body

Let’s get started.

There’s a guy across the way at the coffee shop who’s about to tell me that a little THC helps to activate the CBD.

Do you need THC to activate CBD?

This whole thought comes from the original old-school growers on the illegal side of things.

This belief that the whole plant is better than its components.

The so-call “Entourage Effect”.

There’s no real research for this.

It’s just a gut sense that growers and users had before things went legal.

There’s a great synopsis here from Scientific American:

Our belief is that this stems more from a political motivation to make cannabis legal.

If you can say that benefits come from one component (CBD for example), then that argues against legalizing the plant itself.

Legalization is on its way anyway!

Research is showing very different things.

We have read 100’s of NIH studies on CBD and even CBD with THC.

One thing stands clear. almost all the research is on CBD by itself.

And it’s incredibly positive across a range of different issues.

In many situations, CBD and THC have countering and very different effects on a given issue!

We’ll touch base on this nuanced interaction below in different sections.

In fact, the two tend to neutralize each other (more CBD neutralizes THC) in the body.

CBD is even showing remarkable effects for people addicted to cannabis!

To really get to the heart of this THC to activate CBD question, let’s look at how they work in the body.

How do THC and CBD work in the body

First, THC and CBD are both cannabinoids, a family of different chemicals that can work within our own endocannabinoid system.

We have naturally occurring cannabinoids like Anandamide and 2-AG which are very important to our bodies and brains working correctly.

It just so happens that the cannabis plant also makes cannabinoids.

The two most prevalent are THC and CBD.

They are very different in terms of effects on the body.

We have to get into a little biology to get to the bottom of their interaction.

There are two types of cannabinoid receptors in the body.

  • CB1 primarily in the brain and central nervous system
  • CB2 primarily in the immune and endocrine system but throughout the body

We have CB receptors on almost every type of cell in the body except for red blood cells.

Here’s a big difference.

  • THC tends to influence CB1 receptors in the brain and nervous system
  • CBD tends to influence CB2 receptors in the body and nervous system

This difference speaks to why THC and CBD have very unique effects on the body.

It also speaks to why there are some negatives with THC:

  • Psychoactive – the “high” feeling (unless you’re looking for that)
  • Can be addictive due to interaction with the dopamine system
  • Can cause psychosis or overdose
  • Can cause anxiety, paranoia, hunger, and other effects

CBD does not have these effects since it doesn’t interact with the CB1 receptors in the brain.

Aside from many other effects, CBD has many opposite effects to THC:

  • Calm effect – no high
  • Actually is showing results to counter addiction to many different substances
  • Has shown in MRI’s ability to normalize brain activity during psychosis
  • Has shown powerful anti-anxiety effects and helps to balance hunger hormone levels

It’s the polar opposite!

So how could THC possible by needed to “Activate” CBD?

If we drill down lower, it gets even more interesting.

Does CBD offset THC’s effects in the body

Our poor liver has to do so much heavy lifting in the body.

This is equally true for CBD and THC.

The liver has to process both substances along with 60% of the medications on the market via a specific pathway.

In order for THC to become psychoactive, it has to be metabolized by the liver first.

Guess what blocks this process?


That’s why the ratio of CBD to THC in a given cannabis strain can have such a different effect in terms of the psychoactive effects of THC.

CBD will actually block the metabolism of THC!

It won’t reach those CB1 receptors in the brain in an activated form.

Just a head’s up. the THC levels in today’s pot is so much higher than even a decade ago.

It used to be that there was enough CBD to offset the THC or “mellow” it a bit.

That’s not the case with a lot of cannabis available on the illegal or legal markets.

THC doesn’t activate CBD.

They operate on very separate sets of CB receptors in the body and even counter each other’s effects.

As just one example from our CBD and neuroinflammation article, THC and CBD had an opposing effect on microglia that are key to brain inflammation and schizophrenia!

Interestingly, THC was shown to dysregulate microglia activity which CBD helped to offset.

In pilot experiments, we have replicated the finding that adolescents, low-dose THC activates microglia in the prefrontal cortex via CB1 cannabinoid receptors and increases IL-6 mRNA. The increase in IL- 6 was prevented by concurrent cannabidiol.

THC increases brain inflammation. CBD prevented it.

Also, check out the very differences between THC and CBD on oxidative stress!

There’s an estimate that 80% of the health (not the getting high part) benefits people get from cannabis comes from the CBD!

The high, of course, comes from the THC.

You can learn all about this interplay here:

Let’s take one quick example that research supports.

Can CBD cause anxiety?

CBD’s powerful effects on anxiety are well established now (See CBD and Anxiety here).

First, a little Klingon:

The anxiolytic effects of CBD in humans were first demonstrated in the context of reversing the anxiogenic effects of THC.

Anxiolytic just means anti-anxiety.

That’s attributed to CBD.

Anxiogenic means increasing anxiety.

That’s attributed to THC!

Again. polar opposite.

Interestingly, it’s estimated that 60% of people with allergy and histamine issues are also allergic to THC.

Roughly 40-60% of the population on whole have allergy and histamine issues!

It’s higher for women (tied in with estrogen levels) and higher still for women over 40!

Does that sound like someone you know??

A little simple math and at the high range, roughly 24-36% of the population may be allergic to THC!

There’s a direct tie to histamine release and inflammation in the brain and anxiety.

The “side effects” of THC and other plant materials may just be acute allergic responses.

This goes to why we only deal with CBD Isolate at IndigoNaturals.

The same effect holds true for Full Spectrum CBD as it does for THC.

Back to THC, CBD, and anxiety.

There are numerous examples of opposing and contrarian effects between THC and CBD in the body.

Forget activating CBD. how about canceling out!

Which may be a useful tool in certain situations!

CBD for greening out – help with too much THC

Aside from the bigger question of THC addiction, CBD is showing promise when a person has too much THC.

THC overdose is a very real thing.

Being “Greened Out” is the term for the THC equivalent of drinking too much alcohol.

Does CBD help with this?

The answer is YES!

As we mentioned above, CBD blocks further metabolism of THC by the liver into its active form.

At this point, it’s excreted from the body unactivated (by the liver again).

Maybe more importantly to the poor person greening out, CBD offsets the psychoactive and physiological effects of the excess THC.

Most of the greening out effect of THC is psychoactive:

  • Temporary psychosis and or fear, anxiety, paranoia
  • Acute anxiety (and all its physical manifestations – rapid pulse, shortness of breath, etc)

Both of these effects are directly and positively affected by CBD itself in research.

Still, think THC has to activate CBD in the body?

Always work with a doctor or naturopath with any supplement!

The information provided here is not intended to treat an illness or substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.


I would love to see those studies. Please post links to them. We’re always open to new information.

Every NIH study we’ve looked at show opposing effects of CBD and THC in the body. We’ve listed just a few of them here:

In fact, CBD is shown to offset the negative effects of THC (see CBD if you’re greening out article) along with pregnenolone.

We just wrapped up an article on CBD and appetite. THC and CBD had totally opposite effects.

Outside of appetite stimulation, effects on pain, and maybe cancer (which CBD also affects), it’s hard to argue for THC outside of recreational.

As for sleep, THC can induce drowsiness but it interrupts the most important stage 4 of sleep where the brain removes toxins via the newly discovered lymphatic system. New studies show that interrupted sleep looks just like extreme anxiety in brain scans.

CBD does not interrupt sleep cycles this way. Again…would love to see the research and we’ll ignore that roughly 25% of the population is allergic to THC.

I think the reason people are asking whether THC is needed in the tiniest amount or not because doctors studying this at John Hopkins University, the Mayo Clinic , and New York university all have studies surrounding this pointing doctors in the direction that a minuscule amount of THC is needed for the best results in CBD products. So it’s not just some crazy rumor it’s coming from actual physicians at world renowned hospitals.

That’s an odd ratio. It’s basically 1 to 1 versus almost 1 to 2. I haven’t seen it accurate to the nearest tenth before 🙂 Basically, it’s double the amount of CBD. For anxiety, CBD is probably the better fit. For pain, THC might have more impact there but there are other issues to look at. First, they oppose each other in many pathways. Check out our newest article which goes through these different pathways here:

For pain, we’re more excited about low dose naltrexone, metformin, and even topical ketamine. We’re writing a full review of metformin and LDN as the research is very interesting. Anxiety is clearly in CBD’s wheelhouse. Check out CBD and the mechanisms of anxiety here: Be well!

Can you explain the difference in the potency of 1:1 and 1:19 for CBD being the 19? I’m using CBD oil for pain and anxiety but I have read but still am not sure what to purchase to meet my needs. Do you have some guide lines that can educate me?
Thanks, Beth

Contrary to popular opinion, THC and CBD have opposite effects in the body. Do You Need THC To Activate CBD?